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The staff centered on blocking a protein named synaptotagmin-2, or Syt2. Syt2 is identified on the surface of the granules that contains mucin. Fusion of those granules with the cell membrane depends upon Syt2 interacting with proteins in the mobile membrane.
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In lab tests, SP9 shut down the membrane fusion approach by attaching to Syt2. The researchers next tested SP9 in human airway cells grown in the lab.
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